A pyrogenic reaction is a reaction to sustained and long term intravenous solution given to people, or it can be a reaction to the reuse of needles used in hemodialysis. It can be a reaction to any kind of prolonged infusion of fluids or medications. A pyrogenic reaction causes a fever and other issues in the human body. Hemodialysis is a process by which the waste materials are removed from the urine and blood stream. This is used when the kidneys are failing.